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Single-Molecule Studies of Actin Assembly and Disassembly Factors PDF available through Get Fulltext Research

Smith, Benjamin A. Gelles, Jeff Goode, Bruce L.

Published in Methods in Enzymology

The actin cytoskeleton is very dynamic and highly regulated by multiple associated proteins in vivo. Understanding how this system of proteins functions in the processes of actin network assembly and disassembly requires methods to dissect the mechanisms of activity of individual factors and of multiple factors acting in concert. The advent of sing...

Enhancement of Autophagy by Simvastatin through Inhibition of Rac1-mTOR Signaling Pathway in Coronary Arterial Myocytes PDF available through Get Fulltext Research

Wei, Yu-Miao Li, Xiang Xu, Ming Abais, Justine M. Chen, Yang Riebling, Christopher R. Boini, Krishna M. Li, Pin-Lan Zhang, Yang

Published in Cellular Physiology and Biochemistry

Background/Aims: In addition to their action of lowering blood cholesterol levels, statins modulate biological characteristics and functions of arterial myocytes such as viability, proliferation, apoptosis, survival and contraction. The present study tested whether simvastatin, as a prototype statin, enhances autophagy in coronary arterial myocytes...

Interaction of the New Monofunctional Anticancer Agent Phenanthriplatin With Transporters for Organic Cations PDF available through Get Fulltext Research

Hucke, Anna Park, Ga Young Bauer, Oliver B. Beyer, Georg Köppen, Christina Zeeh, Dorothea Wehe, Christoph A. Sperling, Michael Schröter, Rita Kantauskaitè, Marta ...

Published in Frontiers in Chemistry

Cancer treatment with platinum compounds is an important achievement of modern chemotherapy. However, despite the beneficial effects, the clinical impact of these agents is hampered by the development of drug resistance as well as dose-limiting side effects. The efficacy but also side effects of platinum complexes can be mediated by uptake through ...

Introduction of d-Glutamate at a Critical Residue of Aβ42 Stabilizes a Prefibrillary Aggregate with Enhanced Toxicity. PDF available through Get Fulltext Research

Warner, Christopher J A Dutta, Subrata Foley, Alejandro R Raskatov, Jevgenij A

Published in Chemistry (Weinheim an der Bergstrasse, Germany)

The amyloid beta peptide 42 (Aβ42) is an aggregation-prone peptide that plays a pivotal role in Alzheimer's disease. We report that a subtle perturbation to the peptide through a single chirality change at glutamate 22 leads to a pronounced delay in the β-sheet adoption of the peptide. This was accompanied by an attenuated propensity of the peptide...

Hematopoietic stem cell-specific GFP-expressing transgenic mice generated by genetic excision of a pan-hematopoietic rep... PDF available through Get Fulltext Research

Perez-Cunningham, Jessica Boyer, Scott W Landon, Mark Forsberg, E Camilla

Published in Experimental hematology

Selective labeling of specific cell types by expression of green fluorescent protein (GFP) within the hematopoietic system would have great utility in identifying, localizing, and tracking different cell populations in flow cytometry, microscopy, lineage tracing, and transplantation assays. In this report, we describe the generation and characteriz...

Antimicrobial Peptide LL37 and MAVS Signaling Drive Interferon-β Production by Epidermal Keratinocytes during Skin Injur... PDF available through Get Fulltext Research

Zhang, Ling-Juan Sen, George L Ward, Nicole L Johnston, Andrew Chun, Kimberly Chen, Yifang Adase, Christopher Sanford, James A Gao, Nina Chensee, Melanie ...

Published in Immunity

Type 1 interferons (IFNs) promote inflammation in the skin but the mechanisms responsible for inducing these cytokines are not well understood. We found that IFN-β was abundantly produced by epidermal keratinocytes (KCs) in psoriasis and during wound repair. KC IFN-β production depended on stimulation of mitochondrial antiviral-signaling protein (M...

Response of Vibrio cholerae to Low-Temperature Shifts: CspV Regulation of Type VI Secretion, Biofilm Formation, and Asso...

Townsley, Loni Sison Mangus, Marilou P Mehic, Sanjin Yildiz, Fitnat H

Published in Applied and environmental microbiology

Little is known about how human pathogens respond and adapt to ever-changing parameters of natural habitats outside the human host and how environmental adaptation alters dissemination. Vibrio cholerae, the causative agent of the severe diarrheal disease cholera, experiences fluctuations in temperature in its natural aquatic habitats and during the...

tRNAscan-SE On-line: integrating search and context for analysis of transfer RNA genes. PDF available through Get Fulltext Research

Lowe, Todd M Chan, Patricia P

Published in Nucleic acids research

High-throughput genome sequencing continues to grow the need for rapid, accurate genome annotation and tRNA genes constitute the largest family of essential, ever-present non-coding RNA genes. Newly developed tRNAscan-SE 2.0 has advanced the state-of-the-art methodology in tRNA gene detection and functional prediction, captured by rich new content ...

Phosphono Bisbenzguanidines as Irreversible Dipeptidomimetic Inhibitors and Activity-Based Probes of Matriptase-2.

Häußler, Daniela Mangold, Martin Furtmann, Norbert Braune, Annett Blaut, Michael Bajorath, Jürgen Stirnberg, Marit Gütschow, Michael

Published in Chemistry (Weinheim an der Bergstrasse, Germany)

Matriptase-2, a type II transmembrane serine protease, plays a key role in human iron homeostasis. Inhibition of matriptase-2 is considered as an attractive strategy for the treatment of iron-overload diseases, such as hemochromatosis and β-thalassemia. In the present study, synthetic routes to nine dipeptidomimetic inactivators were developed. Fiv...

Pharyngeal carriage of Neisseria species in the African meningitis belt. PDF available through Get Fulltext Research

Diallo, Kanny Trotter, Caroline Timbine, Youssouf Tamboura, Boubou Sow, Samba O Issaka, Bassira Dano, Ibrahim D Collard, Jean-Marc Dieng, Marietou Diallo, Aldiouma ...

Published in The Journal of infection

Variations in the prevalence of NPNs by time, place and genetic type may contribute to the particular epidemiology of meningococcal disease in the African meningitis belt.

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