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The Stonehouse survey: nasopharyngeal carriage of meningococci and Neisseria lactamica.

Cartwright, Ka Josh Stuart Jones, Dm Noah, Nd

Published in Epidemiology and Infection

A total of 6234 nasopharyngeal swabs was collected during a survey of the population of Stonehouse, Gloucestershire in November 1986 as part of an investigation into an outbreak of meningococcal disease. The overall meningococcal carriage rate was 10.9%. The carriage rate rose with age from 2.1% in the 0- to 4-year-olds to a peak of 24.5% in the 15...

Global optimization of somatic variant identification in cancer genomes with a global community challenge.

Boutros, Pc Ewing, Ad Ellrott, K Norman, Tc Dang, Kk Hu, Y Kellen, Mr Suver, C Bare, Jc Stein, Ld ...

Published in Nature Genetics

Germ versus soma decisions: lessons from flies and worms.

Susan Strome Lehmann, R

Published in Science

The early embryo is formed by the fusion of two germ cells that must generate not only all of the nonreproductive somatic cell types of its body but also the germ cells for the next generation. Therefore, embryo cells face a crucial decision: whether to develop as germ or soma. How is this fundamental decision made and germ cell fate maintained dur...

An outbreak of hepatitis A in Gloucester, UK.

Smith, Mc Watson, Be Majeed, Fa Josh Stuart Cartwright, Ka Room, R Gilkes, Jr

Published in Epidemiology and Infection

During an outbreak of hepatitis A that occurred in Gloucester, UK between September 1989 and January 1991, 162 clinical cases were identified through notifications and laboratory reports, a monthly attack rate of 1.05 per 10,000 residents. The highest attack rate was seen in 5-14-year-olds. There were significant correlations between hepatitis A at...

The Drosophila trithorax group proteins BRM, ASH1 and ASH2 are subunits of distinct protein complexes.

Papoulas, O Beek, Sj Moseley, Sl Mccallum, Cm Sarte, M Shearn, A John Tamkun

Published in Development

The trithorax group gene brahma (brm) encodes an activator of Drosophila homeotic genes that functions as the ATPase subunit of a large protein complex. To determine if BRM physically interacts with other trithorax group proteins, we purified the BRM complex from Drosophila embryos and analyzed its subunit composition. The BRM complex contains at l...

Inferring disease-related pathways using a probabilistic epistasis model.

Kanabar, Pn Vaske, Cj Yeang, Ch Yildiz, Fh Josh Stuart

Published in Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing

High prevalence of tuberculin sensitivity.

Hollyoak, V Pugh, E Josh Stuart Room, R Prior, J

Published in Communicable disease report. CDR review

Managing outbreaks : the public health response.

Josh Stuart

Published in Methods in molecular medicine

Comprehensive practical guidelines for the control of large-scale epidemic meningococcal disease were updated in 1998 by the World Health Organization (WHO) (1). The guidance in this chapter is designed to assist in the management of the smaller-scale outbreaks or clusters, particularly in the educational setting (see Note 1). It focuses on countri...

Use of Pol I-deficient E. coli for functional complementation of DNA polymerase.

Manel Camps Loeb, La

Published in Methods in Molecular Biology

Ancient hot and cold genes and chemotherapy resistance emergence.

Wu, A Zhang, Q Lambert, G Khin, Z Gatenby, Ra Kim, Hj Nader Pourmand Bussey, K Davies, Pc Sturm, Jc ...

Published in Proceedings of the National Academy of Sciences

We use a microfabricated ecology with a doxorubicin gradient and population fragmentation to produce a strong Darwinian selective pressure that drives forward the rapid emergence of doxorubicin resistance in multiple myeloma (MM) cancer cells. RNA sequencing of the resistant cells was used to examine (i) emergence of genes with high de novo substit...

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