Risk and protective factors for meningococcal disease in adolescents: matched cohort study.
...Published in BMJ
Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing beta-catenin binding to the cell adhesion protein c...
Published in The Journal of Cell Biology
Wnt-1 homologs have been identified in invertebrates and vertebrates and play important roles in cellular differentiation and organization. In Drosophila, the products of the segment polarity genes wingless (the Wnt-1 homolog) and armadillo participate in a signal transduction pathway important for cellular boundary formation in embryonic developme...
The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast.
Published in Genes & Development
Chromosome segregation depends on kinetochores, the structures that mediate chromosome attachment to the mitotic spindle. We isolated mutants in IPL1, which encodes a protein kinase, in a screen for budding yeast mutants that have defects in sister chromatid separation and segregation. Cytological tests show that ipl1 mutants can separate sister ch...
Dap-SL: a new site-directed nitroxide spin labeling approach for determining structure and motions in synthesized peptid...
Published in FEBS Letters
A new approach for site-directed placement of nitroxide spin labels in chemically synthesized peptides and proteins is described. The scheme takes advantage of a novel diaminopropionic acid scaffold to independently control backbone and side chain elongation. The result is a spin-labeled side chain, referred to as Dap-SL, in which an amide bond for...
Risk factors for sporadic giardiasis: a case-control study in southwestern England.
Published in Emerging infectious diseases
To investigate risk factors for sporadic infection with Giardia lamblia acquired in the United Kingdom, we conducted a matched case-control study in southwest England in 1998 and 1999. Response rates to a postal questionnaire were 84% (232/276) for cases and 69% (574/828) for controls. In multivariable analysis, swallowing water while swimming (p<0...
Recurrent monocular blindness due to a redundant carotid artery.
Published in Archives of Surgery
Species-specific endogenous retroviruses shape the transcriptional network of the human tumor suppressor protein p53.
Published in Proceedings of the National Academy of Sciences
The evolutionary forces that establish and hone target gene networks of transcription factors are largely unknown. Transposition of retroelements may play a role, but its global importance, beyond a few well described examples for isolated genes, is not clear. We report that LTR class I endogenous retrovirus (ERV) retroelements impact considerably ...
Exploring TCGA Pan-Cancer data at the UCSC Cancer Genomics Browser.
Published in Scientific Reports
The UCSC Cancer Genomics Browser (https://genome-cancer.ucsc.edu) offers interactive visualization and exploration of TCGA genomic, phenotypic, and clinical data, as produced by the Cancer Genome Atlas Research Network. Researchers can explore the impact of genomic alterations on phenotypes by visualizing gene and protein expression, copy number, D...
Unraveling a connection between DNA demethylation repair and cancer.
Published in Molecular Cell
In this issue of Molecular Cell, Dango and Mosammaparast discover that the human oxidative demethylase ALKBH3 functions in complex with a DNA helicase to eliminate N3-methylcytosine lesions from ssDNA and that specific cancer cell lines are dependent on this activity for proliferation (Dango et al., 2011).
Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modificat...
...Published in Nature Biotechnology
Analysis of DNA methylation patterns relies increasingly on sequencing-based profiling methods. The four most frequently used sequencing-based technologies are the bisulfite-based methods MethylC-seq and reduced representation bisulfite sequencing (RRBS), and the enrichment-based techniques methylated DNA immunoprecipitation sequencing (MeDIP-seq) ...
