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Prenatal and postnatal manganese teeth levels and neurodevelopment at 7, 9, and 10.5 years in the CHAMACOS cohort.

Mora, Ana M Arora, Manish Harley, Kim G Kogut, Katherine Parra, Kimberly Hernández-Bonilla, David Gunier, Robert B Bradman, Asa Smith, Donald R Eskenazi, Brenda ...

Published in Environment international

We observed that higher prenatal and early postnatal Mn levels measured in dentine of deciduous teeth, a novel biomarker that provides reliable information on the developmental timing of exposures to Mn, were associated with poorer behavioral outcomes in school-age boys and girls and better motor function, memory, and/or cognitive abilities in scho...

Contrast Sensitivity With a Subretinal Prosthesis and Implications for Efficient Delivery of Visual Information.

Goetz, Georges Smith, Richard Lei, Xin Galambos, Ludwig Kamins, Theodore Mathieson, Keith Sher, Alexander Palanker, Daniel

Published in Investigative ophthalmology & visual science

To evaluate the contrast sensitivity of a degenerate retina stimulated by a photovoltaic subretinal prosthesis, and assess the impact of low contrast sensitivity on transmission of visual information. We measure ex vivo the full-field contrast sensitivity of healthy rat retina stimulated with white light, and the contrast sensitivity of degenerate ...

Temperature affects c-di-GMP signalling and biofilm formation in Vibrio cholerae.

Townsley, Loni Yildiz, Fitnat H

Published in Environmental microbiology

Biofilm formation is crucial to the environmental survival and transmission of Vibrio cholerae, the facultative human pathogen responsible for the disease cholera. During its infectious cycle, V. cholerae experiences fluctuations in temperature within the aquatic environment and during the transition between human host and aquatic reservoirs. In th...

Genome-Directed Lead Discovery: Biosynthesis, Structure Elucidation, and Biological Evaluation of Two Families of Polyen...

Schulze, Christopher J Donia, Mohamed S Siqueira-Neto, Jair L Ray, Debalina Raskatov, Jevgenij A Green, Richard E McKerrow, James H Fischbach, Michael A Linington, Roger G

Published in ACS chemical biology

Marine natural products are an important source of lead compounds against many pathogenic targets. Herein, we report the discovery of lobosamides A-C from a marine actinobacterium, Micromonospora sp., representing three new members of a small but growing family of bacterially produced polyene macrolactams. The lobosamides display growth inhibitory ...

Mammary Stem Cell Self-Renewal Is Regulated by Slit2/Robo1 Signaling through SNAI1 and mINSC. PDF available through Get Fulltext Research

Ballard, Mimmi S Zhu, Anna Iwai, Naomi Stensrud, Michael Mapps, Aurelia Postiglione, Maira Pia Knoblich, Juergen A Hinck, Lindsay

Published in Cell reports

Tissue homeostasis requires somatic stem cell maintenance; however, mechanisms regulating this process during organogenesis are not well understood. Here, we identify asymmetrically renewing basal and luminal stem cells in the mammary end bud. We demonstrate that SLIT2/ROBO1 signaling regulates the choice between self-renewing asymmetric cell divis...

Lead Exposure Risk from Trash Ingestion by the Endangered California Condor (Gymnogyps californianus).

Finkelstein, Myra E Brandt, Joseph Sandhaus, Estelle Grantham, Jesse Mee, Allan Schuppert, Patricia Jill Smith, Donald R

Published in Journal of wildlife diseases

Lead poisoning from ingestion of spent lead ammunition is one of the greatest threats to the recovery of California Condors (Gymnogyps californianus) in the wild. Trash ingestion by condors is well documented, yet the extent that trash presents a lead exposure risk is unknown. We evaluated 1,413 trash items collected from condor nest areas and nest...

C-di-GMP Regulates Motile to Sessile Transition by Modulating MshA Pili Biogenesis and Near-Surface Motility Behavior in...

Jones, Christopher J Utada, Andrew Davis, Kimberly R Thongsomboon, Wiriya Zamorano Sanchez, David Banakar, Vinita Cegelski, Lynette Wong, Gerard C L Yildiz, Fitnat H

Published in PLoS pathogens

In many bacteria, including Vibrio cholerae, cyclic dimeric guanosine monophosphate (c-di-GMP) controls the motile to biofilm life style switch. Yet, little is known about how this occurs. In this study, we report that changes in c-di-GMP concentration impact the biosynthesis of the MshA pili, resulting in altered motility and biofilm phenotypes in...

Design and construction of a silver(I)-loaded cellulose-based wound dressing: trackable and sustained release of silver ...

deBoer, T. R. Chakraborty, I. Mascharak, P. K.

Published in Journal of Materials Science: Materials in Medicine

Although application of silver nitrate and silver sulfadiazine have been shown to be effective in thwarting infections at burn sites, optimization of the delivery of bioactive silver (Ag+) remains as an obstacle due to rapid precipitation and/or insolubility of the silver sources. To circumvent these shortcomings, we have designed a silver(I) compl...

Systematic Identification of Cyclic-di-GMP Binding Proteins in Vibrio cholerae Reveals a Novel Class of Cyclic-di-GMP-Bi...

Roelofs, Kevin G Jones, Christopher J Helman, Sarah R Shang, Xiaoran Orr, Mona W Goodson, Jonathan R Galperin, Michael Y Yildiz, Fitnat H Lee, Vincent T

Published in PLoS pathogens

Cyclic-di-GMP (c-di-GMP) is a ubiquitous bacterial signaling molecule that regulates a variety of complex processes through a diverse set of c-di-GMP receptor proteins. We have utilized a systematic approach to identify c-di-GMP receptors from the pathogen Vibrio cholerae using the Differential Radial Capillary Action of Ligand Assay (DRaCALA). The...

Phenotype-Guided Natural Products Discovery Using Cytological Profiling.

Ochoa, Jessica L Bray, Walter M Lokey, R Scott Linington, Roger G

Published in Journal of natural products

Phenotype-guided natural products discovery is emerging as a useful new discovery tool that addresses challenges in early, unbiased natural product biological annotation. These high-content approaches yield screening results that report directly on the impact of test compounds on cellular processes in target organisms and can be used to predict the...

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