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Phenotype-Guided Natural Products Discovery Using Cytological Profiling.

Ochoa, Jessica L Bray, Walter M Lokey, R Scott Linington, Roger G

Published in Journal of natural products

Phenotype-guided natural products discovery is emerging as a useful new discovery tool that addresses challenges in early, unbiased natural product biological annotation. These high-content approaches yield screening results that report directly on the impact of test compounds on cellular processes in target organisms and can be used to predict the...

Characteristics and Outcome of Streptococcus pneumoniae Endocarditis in the XXI Century: A Systematic Review of 111 Case...

de Egea, Viviana Muñoz, Patricia Valerio, Maricela de Alarcón, Arístides Lepe, José Antonio Miró, José M Gálvez-Acebal, Juan García-Pavía, Pablo Navas, Enrique Goenaga, Miguel Angel ...

Published in Medicine

Streptococcus pneumoniae is an infrequent cause of severe infectious endocarditis (IE). The aim of our study was to describe the epidemiology, clinical and microbiological characteristics, and outcome of a series of cases of S. pneumoniae IE diagnosed in Spain and in a series of cases published since 2000 in the medical literature. We prospectively...

Intron Invasions Trace Algal Speciation and Reveal Nearly Identical Arctic and Antarctic Micromonas Populations. PDF available through Get Fulltext Research

Simmons, Melinda P Bachy, Charles Sudek, Sebastian van Baren, Marijke J Sudek, Lisa Ares, Manuel Jr Worden, Alexandra Z

Published in Molecular biology and evolution

Spliceosomal introns are a hallmark of eukaryotic genes that are hypothesized to play important roles in genome evolution but have poorly understood origins. Although most introns lack sequence homology to each other, new families of spliceosomal introns that are repeated hundreds of times in individual genomes have recently been discovered in a fe...

Cytosolic BMAL1 moonlights as a translation factor.

Michael, Alicia K Asimgil, Hande Partch, Carrie L

Published in Trends in biochemical sciences

It is widely recognized that BMAL1 is an essential subunit of the primary transcription factor that drives rhythmic circadian transcription in the nucleus. In a surprising turn, Lipton et al. now show that BMAL1 rhythmically interacts with translational machinery in the cytosol to stimulate protein synthesis in response to mTOR signaling. Copyright...

Helicobacter pylori CheZ(HP) and ChePep form a novel chemotaxis-regulatory complex distinct from the core chemotaxis sig... PDF available through Get Fulltext Research

Lertsethtakarn, Paphavee Howitt, Michael R Castellon, Juan Amieva, Manuel R Ottemann, Karen M

Published in Molecular microbiology

Chemotaxis is important for Helicobacter pylori to colonize the stomach. Like other bacteria, H. pylori uses chemoreceptors and conserved chemotaxis proteins to phosphorylate the flagellar rotational response regulator, CheY, and modulate the flagellar rotational direction. Phosphorylated CheY is returned to its non-phosphorylated state by phosphat...

H. pylori GPS: Modulating Host Metabolites for Location Sensing. PDF available through Get Fulltext Research

Keilberg, Daniela Ottemann, Karen M

Published in Cell host & microbe

Almost 20 years ago, urea was described as a chemotaxis attractant for Helicobacter pylori. In this issue of Cell Host & Microbe, Huang et al. (2015) report that H. pylori employs its urease enzyme to destroy urea to bring the concentration into a range that provokes an attractant response. Copyright © 2015 Elsevier Inc. All rights reserved.

Chemoprophylaxis and vaccination in preventing subsequent cases of meningococcal disease in household contacts of a case... PDF available through Get Fulltext Research

Telisinghe, L Waite, T D Gobin, M Ronveaux, O Fernandez, K Stuart, J M Scholten, R J P M

Published in Epidemiology and infection

Household contacts of an index case of invasive meningococcal disease (IMD) are at increased risk of acquiring disease. In revising WHO guidance on IMD in sub-Saharan Africa, a systematic review was undertaken to assess the effect of chemoprophylaxis and of vaccination in preventing subsequent cases of IMD in household contacts following an index c...

Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerat... PDF available through Get Fulltext Research

Pietras, Eric M Reynaud, Damien Kang, Yoon-A Carlin, Daniel Calero-Nieto, Fernando J Leavitt, Andrew D Stuart, Joshua M Göttgens, Berthold Passegué, Emmanuelle

Published in Cell stem cell

Despite great advances in understanding the mechanisms underlying blood production, lineage specification at the level of multipotent progenitors (MPPs) remains poorly understood. Here, we show that MPP2 and MPP3 are distinct myeloid-biased MPP subsets that work together with lymphoid-primed MPP4 cells to control blood production. We find that all ...

Transcriptome Profiling of Developing Murine Lens Through RNA Sequencing. PDF available through Get Fulltext Research

Khan, Shahid Y Hackett, Sean F Lee, Mei-Chong W Pourmand, Nader Talbot, C Conover Jr Riazuddin, S Amer

Published in Investigative ophthalmology & visual science

Transcriptome is the entire repertoire of transcripts present in a cell at any particular time. We undertook a next-generation whole transcriptome sequencing approach to gain insight into the transcriptional landscape of the developing mouse lens. We ascertained mouse lenses at six developmental time points including two embryonic (E15 and E18) and...

Optimized Protocol for Simple Extraction of High-Quality Genomic DNA from Clostridium difficile for Whole-Genome Sequenc...

Sim, James Heng Chiak Anikst, Victoria Lohith, Akshar Pourmand, Nader Banaei, Niaz

Published in Journal of clinical microbiology

Successful sequencing of the Clostridium difficile genome requires high-quality genomic DNA (gDNA) as the starting material. gDNA extraction using conventional methods is laborious. We describe here an optimized method for the simple extraction of C. difficile gDNA using the QIAamp DNA minikit, which yielded high-quality sequence reads on the Illum...

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