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The Drosophila kismet gene is related to chromatin-remodeling factors and is required for both segmentation and segment ...

Daubresse, G Deuring, R Moore, L Papoulas, O Zakrajsek, I Waldrip, Wr Scott, Mp Kennison, Ja John Tamkun

Published in Development

The Drosophila kismet gene was identified in a screen for dominant suppressors of Polycomb, a repressor of homeotic genes. Here we show that kismet mutations suppress the Polycomb mutant phenotype by blocking the ectopic transcription of homeotic genes. Loss of zygotic kismet function causes homeotic transformations similar to those associated with...

ATP can be dispensable for prespliceosome formation in yeast.

Perriman, R Ares M, Jr

Published in Genes & Development

The first ATP-dependent step in pre-mRNA splicing involves the stable binding of U2 snRNP to form the prespliceosome. We show that a prespliceosome-like complex forms in the absence of ATP in yeast extracts lacking the U2 suppressor protein CUS2. These complexes display the same pre-mRNA and U snRNA requirements as authentic prespliceosomes and can...

Increasing the visibility, voice, and clout of medical laboratory scientists.

Josh Stuart

Published in Clinical leadership & management review : the journal of CLMA

Medical laboratory science professionals are represented by several national certifying agencies, yet few promote a common professional identity. People outside the profession seldom recognize that medical laboratory scientists (MLSs) perform a myriad of complex laboratory tests. Among medical laboratory scientists, there exists a perceived lack of...

Immunogenicity and arthritogenicity of recombinant CB10 in B10.RIII mice.

Tang, B Brand, Dd Chiang, Tm Josh Stuart Kang, Ah Myers, Lk

Published in The Journal of Immunology

Two major T cell determinants are recognized by I-Ar-specific T cells in CII, the immunodominant CII610-618 (GPAGT AGA R) within CB10 and the subdominant CII445-453 (GPAGP AGE R) within CB8. Although the determinants differ by only two residues, CB8 is capable of inducing collagen-induced arthritis (CIA), while CB10 is not. We, therefore, investiga...

Smoking, the environment and meningococcal disease: a case control study.

Stanwell-Smith, Re Josh Stuart Hughes, Ao Robinson, P Griffin, Mb Cartwright, K

Published in Epidemiology and Infection

This case control study investigated environmental factors in 74 confirmed cases of meningococcal disease (MD). In children aged under 5, passive smoking in the home (30 or more cigarettes daily) was associated with an odds ratio (OR) of 7.5 (95% confidence interval (CI) 1.46-38.66). ORs increased both with the numbers of cigarettes smoked and with...

Timeliness of epidemiological outbreak investigations in peer-reviewed European publications, January 2003 to August 201...

Van De Venter, E Oliver, I Josh Stuart

Published in Eurosurveillance

Timely outbreak investigations are central in containing communicable disease outbreaks; despite this, no guidance currently exists on expectations of timeliness for investigations. A literature review was conducted to assess the length of epidemiological outbreak investigations in Europe in peer-reviewed publications. We determined time intervals ...

Factors influencing student enrollment in clinical laboratory science programs.

Josh Stuart

Published in American clinical laboratory

The results of the phase 1 research revealed three themes concerning junior CLS students decision to enter a single university-based CLS program: 1) influential people, 2) job characteristics, and 3) program characteristics. Phase 2 data ranked the following item descriptors as the most important motivational factors: choice of program based on ge...

The Caenorhabditis elegans maternal-effect sterile proteins, MES-2, MES-3, and MES-6, are associated in a complex in emb...

Xu, L Fong, Y Susan Strome

Published in Proceedings of the National Academy of Sciences

The Caenorhabditis elegans maternal-effect sterile genes, mes-2, mes-3, mes-4, and mes-6, encode nuclear proteins that are essential for germ-line development. They are thought to be involved in a common process because their mutant phenotypes are similar. MES-2 and MES-6 are homologs of Enhancer of zeste and extra sex combs, both members of the Po...

Characterization of a tolerogenic T cell epitope of type II collagen and its relevance to collagen-induced arthritis.

Myers, Lk Terato, K Seyer, Jm Josh Stuart Kang, Ah

Published in The Journal of Immunology

A synthetic peptide representing sequences of type II collagen, (CII 245-270), has previously been used to induce tolerance and suppress arthritis in DBA/1 mice. To determine important residues, a series of peptides, each containing one or two site-directed substitutions, was generated. Mononuclear cells from DBA/1 mice immunized with CII were cult...

Computational reconstruction of ancestral DNA sequences.

Blanchette, M Diallo, Ab Green, Ed Miller, W David Haussler

Published in Methods in Molecular Biology

This chapter introduces the problem of ancestral sequence reconstruction: given a set of extant orthologous DNA genomic sequences (or even whole-genomes), together with a phylogenetic tree relating these sequences, predict the DNA sequence of all ancestral species in the tree. Blanchette et al. (1) have shown that for certain sets of species (in pa...

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