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Revisiting the concept of cancer stem cells in prostate cancer.

Zhu Wang Shen, Mm

Published in Oncogene

The cancer stem cell (CSC) model proposes that cells within a tumor are organized in a hierarchical lineage relationship and display different tumorigenic potential, suggesting that effective therapeutics should target rare CSCs that sustain tumor malignancy. Here we review the current status of studies to identify CSCs in human prostate cancer as ...

Multiple potential germ-line helicases are components of the germ-line-specific P granules of Caenorhabditis elegans.

Gruidl, Me Smith, Pa Kuznicki, Ka Mccrone, Js Kirchner, J Roussell, Dl Susan Strome Bennett, Kl

Published in Proceedings of the National Academy of Sciences

Two components of the germ-line-specific P granules of the nematode Caenorhabditis elgans have been identified using polyclonal antibodies specific for each. Both components are putative germ-line RNA helicases (GLHs) that contain CCHC zinc fingers of the type found in the RNA-binding nucleocapsid proteins of retroviruses. The predicted GLH-1 prote...

The UCSC Known Genes.

Hsu, F Kent, Wj Clawson, H Kuhn, Rm Diekhans, M David Haussler

Published in Bioinformatics

The University of California Santa Cruz (UCSC) Known Genes dataset is constructed by a fully automated process, based on protein data from Swiss-Prot/TrEMBL (UniProt) and the associated mRNA data from Genbank. The detailed steps of this process are described. Extensive cross-references from this dataset to other genomic and proteomic data were cons...

Diffusion models of ion-channel gating and the origin of power-law distributions from single-channel recording.

Glenn Millhauser Salpeter, Ee Oswald, Re

Published in Proceedings of the National Academy of Sciences

The lifetimes of the unitary currents from ion channels, as revealed from single-channel recording, are traditionally thought to follow exponential or multiexponential distributions. The interpretation of these event-time distributions is that the gating process follows Markov kinetics among a small number of states. There is recent evidence, howev...

Feather lead concentrations and (207)Pb/(206)Pb ratios reveal lead exposure history of California Condors (Gymnogyps cal...

Finkelstein, Me George, D Scherbinski, S Gwiazda, R Johnson, M Burnett, J Brandt, J Lawrey, S Pessier, Ap Clark, M ...

Published in Environmental science & technology

Lead poisoning is a primary factor impeding the survival and recovery of the critically endangered California Condor (Gymnogyps californianus). However, the frequency and magnitude of lead exposure in condors is not well-known in part because most blood lead monitoring occurs biannually, and biannual blood samples capture only approximately 10% of ...

Species-specific endogenous retroviruses shape the transcriptional network of the human tumor suppressor protein p53.

Wang, T Zeng, J Lowe, Cb Sellers, Rg Salama, Sr Yang, M Burgess, Sm Brachmann, Rk David Haussler

Published in Proceedings of the National Academy of Sciences

The evolutionary forces that establish and hone target gene networks of transcription factors are largely unknown. Transposition of retroelements may play a role, but its global importance, beyond a few well described examples for isolated genes, is not clear. We report that LTR class I endogenous retrovirus (ERV) retroelements impact considerably ...

ATP mediates rapid microglial response to local brain injury in vivo

Davalos, Dimitrios Grutzendler, Jaime Yang, Guang Kim, Jiyun V Yi Zuo Jung, Steffen Littman, Dan R Dustin, Michael L Gan, Wen-Biao

Published in Nature Neuroscience

A function for kinesin I in the posterior transport of oskar mRNA and Staufen protein.

Brendza, Rp Serbus, Lr Duffy, Jb Saxton, Wm

Published in Science

The asymmetric localization of messenger RNA (mRNA) and protein determinants plays an important role in the establishment of complex body plans. In Drosophila oocytes, the anterior localization of bicoid mRNA and the posterior localization of oskar mRNA are key events in establishing the anterior-posterior axis. Although the mechanisms that drive b...

The classical complement cascade mediates CNS synapse elimination.

Stevens, B Allen, Nj Vazquez, Le Howell, Gr Christopherson, Ks Nouri, N Micheva, Kd Mehalow, Ak Huberman, Ad Stafford, B ...

Published in Cell

During development, the formation of mature neural circuits requires the selective elimination of inappropriate synaptic connections. Here we show that C1q, the initiating protein in the classical complement cascade, is expressed by postnatal neurons in response to immature astrocytes and is localized to synapses throughout the postnatal CNS and re...

Targeted discovery of novel human exons by comparative genomics.

Siepel, A Diekhans, M Brejová, B Langton, L Stevens, M Comstock, Cl Davis, C Ewing, B Oommen, S Lau, C ...

Published in Genome Research

A complete and accurate set of human protein-coding gene annotations is perhaps the single most important resource for genomic research after the human-genome sequence itself, yet the major gene catalogs remain incomplete and imperfect. Here we describe a genome-wide effort, carried out as part of the Mammalian Gene Collection (MGC) project, to ide...

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