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The nucleotide sequence of two silk gland alanine tRNAs: implications for fibroin synthesis and for initiator tRNA struc...

Sprague, Ku Hagenbüchle, O Zuniga, Mc

Published in Cell

The nucleotide sequences of two major alanine tRNAs from the Bombyx mori posterior silk gland have been determined. One of these tRNAs appears to be specific to the silk gland, where its accumulation is associated with the rapid production of fibroin. Both sequences are identical, with the exception of a single nucleotide in the anticodon stem. A s...

Ontology development for a pharmacogenetics knowledge base.

Oliver, De Rubin, Dl Josh Stuart Hewett, M Klein, Te Altman, Rb

Published in Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing

Research directed toward discovering how genetic factors influence a patient s response to drugs requires coordination of data produced from laboratory experiments, computational methods, and clinical studies. A public repository of pharmacogenetic data should accelerate progress in the field of pharmacogenetics by organizing and disseminating publ...

Developmental regulation of SR protein phosphorylation and activity.

Jeremy Sanford Bruzik, Jp

Published in Genes & Development

Serine/arginine-rich splicing factors (SR proteins) are substrates for serine phosphorylation that can regulate SR protein function. We have observed gross changes in SR protein phosphorylation during early development coincident with major zygotic gene activation in the nematode Ascaris lumbricoides. These differences correlate with large-scale ch...

Risk and protective factors for meningococcal disease in adolescents: matched cohort study.

Tully, J Viner, Rm Coen, Pg Josh Stuart Zambon, M Peckham, C Booth, C Klein, N Kaczmarski, E Booy, R ...

Published in BMJ

Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing beta-catenin binding to the cell adhesion protein c...

Lindsay Hinck Nelson, Wj Papkoff, J

Published in The Journal of Cell Biology

Wnt-1 homologs have been identified in invertebrates and vertebrates and play important roles in cellular differentiation and organization. In Drosophila, the products of the segment polarity genes wingless (the Wnt-1 homolog) and armadillo participate in a signal transduction pathway important for cellular boundary formation in embryonic developme...

The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast.

Biggins, S Severin, Ff Needhi Bhalla Sassoon, I Hyman, Aa Murray, Aw

Published in Genes & Development

Chromosome segregation depends on kinetochores, the structures that mediate chromosome attachment to the mitotic spindle. We isolated mutants in IPL1, which encodes a protein kinase, in a screen for budding yeast mutants that have defects in sister chromatid separation and segregation. Cytological tests show that ipl1 mutants can separate sister ch...

Dap-SL: a new site-directed nitroxide spin labeling approach for determining structure and motions in synthesized peptid...

Mcnulty, Jc Thompson, Da Carrasco, Mr Glenn Millhauser

Published in FEBS Letters

A new approach for site-directed placement of nitroxide spin labels in chemically synthesized peptides and proteins is described. The scheme takes advantage of a novel diaminopropionic acid scaffold to independently control backbone and side chain elongation. The result is a spin-labeled side chain, referred to as Dap-SL, in which an amide bond for...

Risk factors for sporadic giardiasis: a case-control study in southwestern England.

Josh Stuart Orr, Hj Warburton, Fg Jeyakanth, S Pugh, C Morris, I Sarangi, J Nichols, G

Published in Emerging infectious diseases

To investigate risk factors for sporadic infection with Giardia lamblia acquired in the United Kingdom, we conducted a matched case-control study in southwest England in 1998 and 1999. Response rates to a postal questionnaire were 84% (232/276) for cases and 69% (574/828) for controls. In multivariable analysis, swallowing water while swimming (p<0...

Recurrent monocular blindness due to a redundant carotid artery.

Doug Kellogg Smith, Ll

Published in Archives of Surgery

SLITs suppress tumor growth in vivo by silencing Sdf1/Cxcr4 within breast epithelium.

Marlow, R Strickland, P Juhee Lee Wu, X Pebenito, M Binnewies, M Le, Ek Moran, A Macias, H Cardiff, Rd ...

Published in Cancer Research

The genes encoding Slits and their Robo receptors are silenced in many types of cancer, including breast, suggesting a role for this signaling pathway in suppressing tumorigenesis. The molecular mechanism underlying these tumor-suppressive effects has not been delineated. Here, we show that loss of Slits, or their Robo1 receptor, in murine mammary ...

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