Wang, Xin Juan, Liran Lv, Junjie Wang, Kejun Sanford, Jeremy R Liu, Yunlong
Published in
BMC Genomics
BackgroundRNA-binding proteins (RBPs) play diverse roles in eukaryotic RNA processing. Despite their pervasive functions in coding and noncoding RNA biogenesis and regulation, elucidating the sequence specificities that define protein-RNA interactions remains a major challenge. Recently, CLIP-seq (Cross-linking immunoprecipitation followed by high-...
Baertsch, Robert Diekhans, Mark Kent, W James Haussler, David Brosius, Jürgen
Published in
BMC Genomics
BackgroundEvolution via point mutations is a relatively slow process and is unlikely to completely explain the differences between primates and other mammals. By contrast, 45% of the human genome is composed of retroposed elements, many of which were inserted in the primate lineage. A subset of retroposed mRNAs (retrocopies) shows strong evidence o...
Wei, Yu-Miao Li, Xiang Xu, Ming Abais, Justine M. Chen, Yang Riebling, Christopher R. Boini, Krishna M. Li, Pin-Lan Zhang, Yang
Published in
Cellular Physiology and Biochemistry
Background/Aims: In addition to their action of lowering blood cholesterol levels, statins modulate biological characteristics and functions of arterial myocytes such as viability, proliferation, apoptosis, survival and contraction. The present study tested whether simvastatin, as a prototype statin, enhances autophagy in coronary arterial myocytes...
Wang, Xin Wang, Guohua Shen, Changyu Li, Lang Wang, Xinguo Mooney, Sean D Edenberg, Howard J Sanford, Jeremy R Liu, Yunlong
Published in
BMC Genomics
Massively parallel pyrosequencing is a high-throughput technology that can sequence hundreds of thousands of DNA/RNA fragments in a single experiment. Combining it with immunoprecipitation-based biochemical assays, such as cross-linking immunoprecipitation (CLIP), provides a genome-wide method to detect the sites at which proteins bind DNA or RNA. ...
Vohr, Samuel H. Buen Abad Najar, Carlos Fernando Shapiro, Beth Green, Richard E.
Published in
BMC Genomics
BackgroundDetermining whether two DNA samples originate from the same individual is difficult when the amount of retrievable DNA is limited. This is often the case for ancient, historic, and forensic samples. The most widely used approaches rely on amplification of a defined panel of multi-allelic markers and comparison to similar data from other s...
