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Electrostatic Similarity Analysis of Human β-Defensin Binding in the Melanocortin System. PDF available through Get Fulltext Research

Nix, Matthew A Kaelin, Christopher B Palomino, Rafael Miller, Jillian L Barsh, Gregory S Millhauser, Glenn L

Published in Biophysical journal

The β-defensins are a class of small cationic proteins that serve as components of numerous systems in vertebrate biology, including the immune and melanocortin systems. Human β-defensin 3 (HBD3), which is produced in the skin, has been found to bind to melanocortin receptors 1 and 4 through complementary electrostatics, a unique mechanism of ligan...

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