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Hematopoietic development at high altitude: blood stem cells put to the test.

Zovein, Ann C Forsberg, E Camilla

Published in Development (Cambridge, England)

In February 2015, over 200 scientists gathered for the Keystone Hematopoiesis meeting, which was held at the scenic Keystone Resort in Keystone, Colorado, USA. The meeting organizers, Patricia Ernst, Hanna Mikkola and Timm Schroeder, put together an exciting program, during which field leaders and new investigators presented discoveries that spanne...

Kinesin-1 tail autoregulation and microtubule-binding regions function in saltatory transport but not ooplasmic streamin...

Moua, Pangkong Fullerton, Donna Serbus, Laura R Warrior, Rahul Saxton, William M

Published in Development (Cambridge, England)

synMuv B proteins antagonize germline fate in the intestine and ensure C. elegans survival.

Petrella, Lisa N Wang, Wenchao Spike, Caroline A Rechtsteiner, Andreas Reinke, Valerie Strome, Susan

Published in Development (Cambridge, England)

Previous studies demonstrated that a subset of synMuv B mutants ectopically misexpress germline-specific P-granule proteins in their somatic cells, suggesting a failure to properly orchestrate a soma/germline fate decision. Surprisingly, this fate confusion does not affect viability at low to ambient temperatures. Here, we show that, when grown at ...

DEPS-1 promotes P-granule assembly and RNA interference in C. elegans germ cells.

Spike, Caroline A Bader, Jason Reinke, Valerie Strome, Susan

Published in Development (Cambridge, England)

P granules are germ-cell-specific cytoplasmic structures containing RNA and protein, and required for proper germ cell development in C. elegans. PGL-1 and GLH-1 were previously identified as critical components of P granules. We have identified a new P-granule-associated protein, DEPS-1, the loss of which disrupts P-granule structure and function....

Kinesin-1 tail autoregulation and microtubule-binding regions function in saltatory transport but not ooplasmic streamin...

Moua, Pangkong Fullerton, Donna Serbus, Laura R Warrior, Rahul Saxton, William M

Published in Development (Cambridge, England)

The N-terminal head domain of kinesin heavy chain (Khc) is well known for generating force for transport along microtubules in cytoplasmic organization processes during metazoan development, but the functions of the C-terminal tail are not clear. To address this, we studied the effects of tail mutations on mitochondria transport, determinant mRNA l...

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