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Identification of a calcium-controlled negative regulatory system affecting Vibrio cholerae biofilm formation.

Bilecen, Kivanc Yildiz, Fitnat H

Published in Environmental microbiology

Vibrio cholerae's capacity to cause outbreaks of cholera is linked to its survival and adaptability to changes in aquatic environments. One of the environmental conditions that can vary in V. cholerae's natural aquatic habitats is calcium (Ca(+2)). In this study, we investigated the response of V. cholerae to changes in extracellular Ca(2+) levels....

Temperature affects c-di-GMP signalling and biofilm formation in Vibrio cholerae.

Townsley, Loni Yildiz, Fitnat H

Published in Environmental microbiology

Biofilm formation is crucial to the environmental survival and transmission of Vibrio cholerae, the facultative human pathogen responsible for the disease cholera. During its infectious cycle, V. cholerae experiences fluctuations in temperature within the aquatic environment and during the transition between human host and aquatic reservoirs. In th...

The transcriptional regulator, CosR, controls compatible solute biosynthesis and transport, motility and biofilm formati...

Shikuma, Nicholas J Davis, Kimberly R Fong, Jiunn N C Yildiz, Fitnat H

Published in Environmental microbiology

Vibrio cholerae inhabits aquatic environments and colonizes the human digestive tract to cause the disease cholera. In these environments, V. cholerae copes with fluctuations in salinity and osmolarity by producing and transporting small, organic, highly soluble molecules called compatible solutes, which counteract extracellular osmotic pressure. C...

How Helicobacter pylori senses, targets and interacts with the gastric epithelium. PDF available through Get Fulltext Research

Keilberg, Daniela Ottemann, Karen M

Published in Environmental microbiology

Helicobacter pylori is a human-specific pathogen that chronically infects about 50% of the world's population. After travelling through the harsh environment of the stomach lumen, H. pylori colonizes the mucosal surface and within the glands of the human stomach. During colonization, H. pylori uses motility and its chemotaxis signalling system to s...

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