Epelman, S Lavine, Kj Beaudin, Ae Sojka, Dk Carrero, Ja Calderon, B Brija, T Gautier, El Ivanov, S Satpathy, At
...
Published in
Immunity
Cardiac macrophages are crucial for tissue repair after cardiac injury but are not well characterized. Here we identify four populations of cardiac macrophages. At steady state, resident macrophages were primarily maintained through local proliferation. However, after macrophage depletion or during cardiac inflammation, Ly6c(hi) monocytes contribut...
Spiliotis, Et Manley, H Osorio, M Zúñiga, Mc Edidin, M
Published in
Immunity
It has been assumed that upon dissociation from TAP, MHC class I molecules exit the ER by nonselective bulk flow. We now show that exit must occur by association with cargo receptors. Inconsistent with exit by bulk flow, loading of MHC class I molecules with high-affinity peptides triggers dissociation from TAP but has no effect on rates of ER-to-G...
Hoeffel, Guillaume Chen, Jinmiao Lavin, Yonit Low, Donovan Almeida, Francisca F See, Peter Beaudin, Anna E Lum, Josephine Low, Ivy Forsberg, E Camilla
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Published in
Immunity
Although classified as hematopoietic cells, tissue-resident macrophages (MFs) arise from embryonic precursors that seed the tissues prior to birth to generate a self-renewing population, which is maintained independently of adult hematopoiesis. Here we reveal the identity of these embryonic precursors using an in utero MF-depletion strategy and fat...
Zhang, Ling-Juan Sen, George L Ward, Nicole L Johnston, Andrew Chun, Kimberly Chen, Yifang Adase, Christopher Sanford, James A Gao, Nina Chensee, Melanie
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Published in
Immunity
Type 1 interferons (IFNs) promote inflammation in the skin but the mechanisms responsible for inducing these cytokines are not well understood. We found that IFN-β was abundantly produced by epidermal keratinocytes (KCs) in psoriasis and during wound repair. KC IFN-β production depended on stimulation of mitochondrial antiviral-signaling protein (M...
Hashimoto, Daigo Chow, Andrew Noizat, Clara Teo, Pearline Beasley, Mary Beth Leboeuf, Marylene Becker, Christian D See, Peter Price, Jeremy Lucas, Daniel
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Published in
Immunity
Despite accumulating evidence suggesting local self-maintenance of tissue macrophages in the steady state, the dogma remains that tissue macrophages derive from monocytes. Using parabiosis and fate-mapping approaches, we confirmed that monocytes do not show significant contribution to tissue macrophages in the steady state. Similarly, we found that...
Epelman, S Lavine, Kj Beaudin, Ae Sojka, Dk Carrero, Ja Calderon, B Brija, T Gautier, El Ivanov, S Satpathy, At
...
Published in
Immunity
Cardiac macrophages are crucial for tissue repair after cardiac injury but are not well characterized. Here we identify four populations of cardiac macrophages. At steady state, resident macrophages were primarily maintained through local proliferation. However, after macrophage depletion or during cardiac inflammation, Ly6c(hi) monocytes contribut...
Epelman, S Lavine, Kj Beaudin, Ae Sojka, Dk Carrero, Ja Calderon, B Brija, T Gautier, El Ivanov, S Satpathy, At
...
Published in
Immunity
Cardiac macrophages are crucial for tissue repair after cardiac injury but are not well characterized. Here we identify four populations of cardiac macrophages. At steady state, resident macrophages were primarily maintained through local proliferation. However, after macrophage depletion or during cardiac inflammation, Ly6c(hi) monocytes contribut...
