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Phenotype-Guided Natural Products Discovery Using Cytological Profiling.

Ochoa, Jessica L Bray, Walter M Lokey, R Scott Linington, Roger G

Published in Journal of natural products

Phenotype-guided natural products discovery is emerging as a useful new discovery tool that addresses challenges in early, unbiased natural product biological annotation. These high-content approaches yield screening results that report directly on the impact of test compounds on cellular processes in target organisms and can be used to predict the...

Natural product libraries to accelerate the high-throughput discovery of therapeutic leads.

Johnson, Tyler A Sohn, Johann Inman, Wayne D Estee, Samarkand A Loveridge, Steven T Vervoort, Helene C Tenney, Karen Liu, Junke Ang, Kenny Kean-Hooi Ratnam, Joseline ...

Published in Journal of natural products

A high-throughput (HT) paradigm generating LC-MS-UV-ELSD-based natural product libraries to discover compounds with new bioactivities and or molecular structures is presented. To validate this methodology, an extract of the Indo-Pacific marine sponge Cacospongia mycofijiensis was evaluated using assays involving cytoskeletal profiling, tumor cell l...

A beta-carboline alkaloid from the Papua New Guinea marine sponge hyrtios reticulatus.

Inman, Wayne D Bray, Walter M Gassner, Nadine C Lokey, R Scott Tenney, Karen Shen, Young Yongchun Tendyke, Karen Suh, Ted Crews, Phillip

Published in Journal of natural products

A new 1-imidazoyl-3-carboxy-6-hydroxy-beta-carboline alkaloid, named hyrtiocarboline (1), was isolated from a Papua New Guinea marine sponge, Hyrtios reticulatus. The structure was elucidated from spectroscopic data, including (1)H-(15)N HMBC NMR experiments, which provided complementary (15)N chemical shift information in support of the structure....

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