Zhu Wang Huang, J Kalderon, D
Published in
Nature Communications
The mechanisms underlying adult stem cell behaviour are likely to be diverse and have not yet been investigated systematically. Here we conducted an unbiased genetic screen using Drosophila ovarian follicle stem cells to probe essential functions regulating self-renewal of epithelial stem cells. Surprisingly, we find that niche adhesion emerges as ...
Utada, Andrew S Bennett, Rachel R Fong, Jiunn C N Gibiansky, Maxsim L Yildiz, Fitnat H Golestanian, Ramin Wong, Gerard C L
Published in
Nature communications
We show that Vibrio cholerae, the causative agent of cholera, use their flagella and mannose-sensitive hemagglutinin (MSHA) type IV pili synergistically to switch between two complementary motility states that together facilitate surface selection and attachment. Flagellar rotation counter-rotates the cell body, causing MSHA pili to have periodic m...
Parks, Jw Michael Stone
Published in
Nature Communications
The human telomerase reverse transcriptase (hTERT) utilizes a template within the integral RNA subunit (hTR) to direct extension of telomeres. Telomerase exhibits repeat addition processivity (RAP) and must therefore translocate the nascent DNA product into a new RNA:DNA hybrid register to prime each round of telomere repeat synthesis. Here, we use...
Khan, Shahid Y Vasanth, Shivakumar Kabir, Firoz Gottsch, John D Khan, Arif O Chaerkady, Raghothama Lee, Mei-Chong W Leitch, Carmen C Ma, Zhiwei Laux, Julie
...
Published in
Nature communications
FOXE3 is a lens-specific transcription factor that has been associated with anterior segment ocular dysgenesis. To determine the transcriptional target(s) of FOXE3 that are indispensable for the anterior segment development, we examined the transcriptome and the proteome of cells expressing truncated FOXE3 responsible for Peters anomaly identified ...
Rg, De Bruin L, Shiue J, Prins Hc, De Boer A, Singh Ws, Fagg Jm, Van Gils Jm, Duijs S, Katzman Ao, Kraaijeveld
...
Published in
Nature Communications
A hallmark of inflammatory diseases is the excessive recruitment and influx of monocytes to sites of tissue damage and their ensuing differentiation into macrophages. Numerous stimuli are known to induce transcriptional changes associated with macrophage phenotype, but posttranscriptional control of human macrophage differentiation is less well und...
Parks, Jw Michael Stone
Published in
Nature Communications
The human telomerase reverse transcriptase (hTERT) utilizes a template within the integral RNA subunit (hTR) to direct extension of telomeres. Telomerase exhibits repeat addition processivity (RAP) and must therefore translocate the nascent DNA product into a new RNA:DNA hybrid register to prime each round of telomere repeat synthesis. Here, we use...
Zhu Wang Huang, J Kalderon, D
Published in
Nature Communications
The mechanisms underlying adult stem cell behaviour are likely to be diverse and have not yet been investigated systematically. Here we conducted an unbiased genetic screen using Drosophila ovarian follicle stem cells to probe essential functions regulating self-renewal of epithelial stem cells. Surprisingly, we find that niche adhesion emerges as ...
