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Drosophila follicle stem cells are regulated by proliferation and niche adhesion as well as mitochondria and ROS. PDF available through Get Fulltext Research

Zhu Wang Huang, J Kalderon, D

Published in Nature Communications

The mechanisms underlying adult stem cell behaviour are likely to be diverse and have not yet been investigated systematically. Here we conducted an unbiased genetic screen using Drosophila ovarian follicle stem cells to probe essential functions regulating self-renewal of epithelial stem cells. Surprisingly, we find that niche adhesion emerges as ...

Vibrio cholerae use pili and flagella synergistically to effect motility switching and conditional surface attachment. PDF available through Get Fulltext Research

Utada, Andrew S Bennett, Rachel R Fong, Jiunn C N Gibiansky, Maxsim L Yildiz, Fitnat H Golestanian, Ramin Wong, Gerard C L

Published in Nature communications

We show that Vibrio cholerae, the causative agent of cholera, use their flagella and mannose-sensitive hemagglutinin (MSHA) type IV pili synergistically to switch between two complementary motility states that together facilitate surface selection and attachment. Flagellar rotation counter-rotates the cell body, causing MSHA pili to have periodic m...

Coordinated DNA dynamics during the human telomerase catalytic cycle. PDF available through Get Fulltext Research

Parks, Jw Michael Stone

Published in Nature Communications

The human telomerase reverse transcriptase (hTERT) utilizes a template within the integral RNA subunit (hTR) to direct extension of telomeres. Telomerase exhibits repeat addition processivity (RAP) and must therefore translocate the nascent DNA product into a new RNA:DNA hybrid register to prime each round of telomere repeat synthesis. Here, we use...

FOXE3 contributes to Peters anomaly through transcriptional regulation of an autophagy-associated protein termed DNAJB1.... PDF available through Get Fulltext Research

Khan, Shahid Y Vasanth, Shivakumar Kabir, Firoz Gottsch, John D Khan, Arif O Chaerkady, Raghothama Lee, Mei-Chong W Leitch, Carmen C Ma, Zhiwei Laux, Julie ...

Published in Nature communications

FOXE3 is a lens-specific transcription factor that has been associated with anterior segment ocular dysgenesis. To determine the transcriptional target(s) of FOXE3 that are indispensable for the anterior segment development, we examined the transcriptome and the proteome of cells expressing truncated FOXE3 responsible for Peters anomaly identified ...

Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene exp... PDF available through Get Fulltext Research

Rg, De Bruin L, Shiue J, Prins Hc, De Boer A, Singh Ws, Fagg Jm, Van Gils Jm, Duijs S, Katzman Ao, Kraaijeveld ...

Published in Nature Communications

A hallmark of inflammatory diseases is the excessive recruitment and influx of monocytes to sites of tissue damage and their ensuing differentiation into macrophages. Numerous stimuli are known to induce transcriptional changes associated with macrophage phenotype, but posttranscriptional control of human macrophage differentiation is less well und...

Coordinated DNA dynamics during the human telomerase catalytic cycle. PDF available through Get Fulltext Research

Parks, Jw Michael Stone

Published in Nature Communications

The human telomerase reverse transcriptase (hTERT) utilizes a template within the integral RNA subunit (hTR) to direct extension of telomeres. Telomerase exhibits repeat addition processivity (RAP) and must therefore translocate the nascent DNA product into a new RNA:DNA hybrid register to prime each round of telomere repeat synthesis. Here, we use...

Drosophila follicle stem cells are regulated by proliferation and niche adhesion as well as mitochondria and ROS. PDF available through Get Fulltext Research

Zhu Wang Huang, J Kalderon, D

Published in Nature Communications

The mechanisms underlying adult stem cell behaviour are likely to be diverse and have not yet been investigated systematically. Here we conducted an unbiased genetic screen using Drosophila ovarian follicle stem cells to probe essential functions regulating self-renewal of epithelial stem cells. Surprisingly, we find that niche adhesion emerges as ...

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