Genomic analysis of 6,000-year-old cultivated grain illuminates the domestication history of barley.
...Published in Nature Genetics
Global optimization of somatic variant identification in cancer genomes with a global community challenge.
...
Published in Nature Genetics
dbEST—database for "expressed sequence tags".
Published in Nature Genetics
Variation in genome-wide mutation rates within and between human families.
...Published in Nature genetics
J.B.S. Haldane proposed in 1947 that the male germline may be more mutagenic than the female germline. Diverse studies have supported Haldane's contention of a higher average mutation rate in the male germline in a variety of mammals, including humans. Here we present, to our knowledge, the first direct comparative analysis of male and female germl...
The Cancer Genome Atlas Pan-Cancer analysis project.
Published in Nature genetics
The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a major opportunity to develop an integrated picture of commonalities, differences and emergent themes across tumor lineages. The Pa...
Global optimization of somatic variant identification in cancer genomes with a global community challenge.
...
Published in Nature Genetics
Global optimization of somatic variant identification in cancer genomes with a global community challenge.
...
Published in Nature Genetics
The splicing regulator Rbfox1 (A2BP1) controls neuronal excitation in the mammalian brain.
Published in Nature genetics
The Rbfox family of RNA binding proteins regulates alternative splicing of many important neuronal transcripts, but its role in neuronal physiology is not clear. We show here that central nervous system-specific deletion of the gene encoding Rbfox1 results in heightened susceptibility to spontaneous and kainic acid-induced seizures. Electrophysiolo...
