Ramasamy, Adaikalavan Trabzuni, Daniah Gibbs, J Raphael Dillman, Allissa Hernandez, Dena G Arepalli, Sampath Walker, Robert Smith, Colin Ilori, Gigaloluwa Peter Shabalin, Andrey A
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Published in
Nucleic acids research
Polymorphisms in the target mRNA sequence can greatly affect the binding affinity of microarray probe sequences, leading to false-positive and false-negative expression quantitative trait locus (QTL) signals with any other polymorphisms in linkage disequilibrium. We provide the most complete solution to this problem, by using the latest genome and ...
Lowe, Todd M Chan, Patricia P
Published in
Nucleic acids research
High-throughput genome sequencing continues to grow the need for rapid, accurate genome annotation and tRNA genes constitute the largest family of essential, ever-present non-coding RNA genes. Newly developed tRNAscan-SE 2.0 has advanced the state-of-the-art methodology in tRNA gene detection and functional prediction, captured by rich new content ...
Raney, Brian J Cline, Melissa S Rosenbloom, Kate R Dreszer, Timothy R Learned, Katrina Barber, Galt P Meyer, Laurence R Sloan, Cricket A Malladi, Venkat S Roskin, Krishna M
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Published in
Nucleic acids research
The ENCODE project is an international consortium with a goal of cataloguing all the functional elements in the human genome. The ENCODE Data Coordination Center (DCC) at the University of California, Santa Cruz serves as the central repository for ENCODE data. In this role, the DCC offers a collection of high-throughput, genome-wide data generated...
Long, Xi Parks, Joseph W Bagshaw, Clive R Stone, Michael D
Published in
Nucleic acids research
Single-molecule techniques facilitate analysis of mechanical transitions within nucleic acids and proteins. Here, we describe an integrated fluorescence and magnetic tweezers instrument that permits detection of nanometer-scale DNA structural rearrangements together with the application of a wide range of stretching forces to individual DNA molecul...
