Stutzbach, Lauren D Xie, Sharon X Naj, Adam C Albin, Roger Gilman, Sid Lee, Virginia M Y Trojanowski, John Q Devlin, Bernie Schellenberg, Gerard D
Published in
Acta Neuropathologica Communications
BackgroundProgressive supranuclear palsy (PSP) is a neurodegenerative disorder pathologically characterized by intracellular tangles of hyperphosphorylated tau protein distributed throughout the neocortex, basal ganglia, and brainstem. A genome-wide association study identified EIF2AK3 as a risk factor for PSP. EIF2AK3 encodes PERK, part of the end...
Lowe, Todd M Chan, Patricia P
Published in
Nucleic acids research
High-throughput genome sequencing continues to grow the need for rapid, accurate genome annotation and tRNA genes constitute the largest family of essential, ever-present non-coding RNA genes. Newly developed tRNAscan-SE 2.0 has advanced the state-of-the-art methodology in tRNA gene detection and functional prediction, captured by rich new content ...
Raney, Brian J Cline, Melissa S Rosenbloom, Kate R Dreszer, Timothy R Learned, Katrina Barber, Galt P Meyer, Laurence R Sloan, Cricket A Malladi, Venkat S Roskin, Krishna M
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Published in
Nucleic acids research
The ENCODE project is an international consortium with a goal of cataloguing all the functional elements in the human genome. The ENCODE Data Coordination Center (DCC) at the University of California, Santa Cruz serves as the central repository for ENCODE data. In this role, the DCC offers a collection of high-throughput, genome-wide data generated...
Rhead, Brooke Karolchik, Donna Kuhn, Robert M Hinrichs, Angie S Zweig, Ann S Fujita, Pauline A Diekhans, Mark Smith, Kayla E Rosenbloom, Kate R Raney, Brian J
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Published in
Nucleic acids research
The University of California, Santa Cruz (UCSC) Genome Browser website (http://genome.ucsc.edu/) provides a large database of publicly available sequence and annotation data along with an integrated tool set for examining and comparing the genomes of organisms, aligning sequence to genomes, and displaying and sharing users' own annotation data. As ...
Akiyama, Benjamin M Parks, Joseph W Stone, Michael D
Published in
Nucleic acids research
Telomerase is an enzyme that adds repetitive DNA sequences to the ends of chromosomes and consists of two main subunits: the telomerase reverse transcriptase (TERT) protein and an associated telomerase RNA (TER). The telomerase essential N-terminal (TEN) domain is a conserved region of TERT proposed to mediate DNA substrate interactions. Here, we h...
Chan, Patricia P Lowe, Todd M
Published in
Nucleic acids research
Transfer RNAs represent the largest, most ubiquitous class of non-protein coding RNA genes found in all living organisms. The tRNAscan-SE search tool has become the de facto standard for annotating tRNA genes in genomes, and the Genomic tRNA Database (GtRNAdb) was created as a portal for interactive exploration of these gene predictions. Since its ...
Long, Xi Parks, Joseph W Bagshaw, Clive R Stone, Michael D
Published in
Nucleic acids research
Single-molecule techniques facilitate analysis of mechanical transitions within nucleic acids and proteins. Here, we describe an integrated fluorescence and magnetic tweezers instrument that permits detection of nanometer-scale DNA structural rearrangements together with the application of a wide range of stretching forces to individual DNA molecul...
