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Early onset prion disease from octarepeat expansion correlates with copper binding properties. PDF available through Get Fulltext Research

Stevens, Daniel J Walter, Eric D Rodríguez, Abel Draper, David Davies, Paul Brown, David R Millhauser, Glenn L

Published in PLoS pathogens

Insertional mutations leading to expansion of the octarepeat domain of the prion protein (PrP) are directly linked to prion disease. While normal PrP has four PHGGGWGQ octapeptide segments in its flexible N-terminal domain, expanded forms may have up to nine additional octapeptide inserts. The type of prion disease segregates with the degree of exp...

IscR is essential for yersinia pseudotuberculosis type III secretion and virulence. PDF available through Get Fulltext Research

Miller, Halie K Kwuan, Laura Schwiesow, Leah Bernick, David L Mettert, Erin Ramirez, Hector A Ragle, James M Chan, Patricia P Kiley, Patricia J Lowe, Todd M ...

Published in PLoS pathogens

Type III secretion systems (T3SS) are essential for virulence in dozens of pathogens, but are not required for growth outside the host. Therefore, the T3SS of many bacterial species are under tight regulatory control. To increase our understanding of the molecular mechanisms behind T3SS regulation, we performed a transposon screen to identify genes...

Vibrio cholerae Response Regulator VxrB Controls Colonization and Regulates the Type VI Secretion System. PDF available through Get Fulltext Research

Cheng, Andrew T Ottemann, Karen M Yildiz, Fitnat H

Published in PLoS pathogens

Two-component signal transduction systems (TCS) are used by bacteria to sense and respond to their environment. TCS are typically composed of a sensor histidine kinase (HK) and a response regulator (RR). The Vibrio cholerae genome encodes 52 RR, but the role of these RRs in V. cholerae pathogenesis is largely unknown. To identify RRs that control V...

C-di-GMP Regulates Motile to Sessile Transition by Modulating MshA Pili Biogenesis and Near-Surface Motility Behavior in... PDF available through Get Fulltext Research

Jones, Christopher J Utada, Andrew Davis, Kimberly R Thongsomboon, Wiriya Zamorano Sanchez, David Banakar, Vinita Cegelski, Lynette Wong, Gerard C L Yildiz, Fitnat H

Published in PLoS pathogens

In many bacteria, including Vibrio cholerae, cyclic dimeric guanosine monophosphate (c-di-GMP) controls the motile to biofilm life style switch. Yet, little is known about how this occurs. In this study, we report that changes in c-di-GMP concentration impact the biosynthesis of the MshA pili, resulting in altered motility and biofilm phenotypes in...

Filamentation temperature-sensitive protein Z (FtsZ) of Wolbachia, endosymbiont of Wuchereria bancrofti: A potential tar... PDF available through Get Fulltext Research

Sharma, Rohit Hoti, S.L. Vasuki, V. Sankari, T. Meena, R.L. Das, P.K.

Published in Acta Tropica

Lymphatic filariasis (LF) is a leading cause of morbidity in the tropical world. It is caused by the filarial parasites Wuchereria bancrofti, Brugia malayi and Brugia timori and transmitted by vector mosquitoes. Currently a programme for the elimination of LF, Global programme for Elimination of Lymphatic Filariasis (GPELF), is underway with the st...

Systematic Identification of Cyclic-di-GMP Binding Proteins in Vibrio cholerae Reveals a Novel Class of Cyclic-di-GMP-Bi... PDF available through Get Fulltext Research

Roelofs, Kevin G Jones, Christopher J Helman, Sarah R Shang, Xiaoran Orr, Mona W Goodson, Jonathan R Galperin, Michael Y Yildiz, Fitnat H Lee, Vincent T

Published in PLoS pathogens

Cyclic-di-GMP (c-di-GMP) is a ubiquitous bacterial signaling molecule that regulates a variety of complex processes through a diverse set of c-di-GMP receptor proteins. We have utilized a systematic approach to identify c-di-GMP receptors from the pathogen Vibrio cholerae using the Differential Radial Capillary Action of Ligand Assay (DRaCALA). The...

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