Kistler, Logan Montenegro, Alvaro Smith, Bruce D Gifford, John A Green, Richard E Newsom, Lee A Shapiro, Beth
Published in
Proceedings of the National Academy of Sciences of the United States of America
Bottle gourd (Lagenaria siceraria) was one of the first domesticated plants, and the only one with a global distribution during pre-Columbian times. Although native to Africa, bottle gourd was in use by humans in east Asia, possibly as early as 11,000 y ago (BP) and in the Americas by 10,000 BP. Despite its utilitarian importance to diverse human p...
Chamberlain, Cp Waldbauer, Jr Fox-Dobbs, K Newsome, Sd Koch, Pl Don Smith Church, Me Chamberlain, Sd Sorenson, Kj Risebrough, R
...
Published in
Proceedings of the National Academy of Sciences
We used carbon and nitrogen isotopes to investigate changes in the diet of California condors from the Pleistocene to the recent. During the Pleistocene, condors from California fed on both terrestrial megafauna and marine mammals. Early accounts reported condors feeding on the carcasses of marine mammals, but by the late 1700s, condor diets had sh...
Schreiber, J Wescoe, Zl Abu-Shumays, R Vivian, Jt Baatar, B Kevin Karplus Mark Akeson
Published in
Proceedings of the National Academy of Sciences
Cytosine, 5-methylcytosine, and 5-hydroxymethylcytosine were identified during translocation of single DNA template strands through a modified Mycobacterium smegmatis porin A (M2MspA) nanopore under control of phi29 DNA polymerase. This identification was based on three consecutive ionic current states that correspond to passage of modified or unmo...
Michael Stone Bryant, Z Crisona, Nj Smith, Sb Vologodskii, A Bustamante, C Cozzarelli, Nr
Published in
Proceedings of the National Academy of Sciences
Escherichia coli topoisomerase (Topo) IV is an essential type II Topo that removes DNA entanglements created during DNA replication. Topo IV relaxes (+) supercoils much faster than (-) supercoils, promoting replication while sparing the essential (-) supercoils. Here, we investigate the mechanism underlying this chiral preference. Using DNA binding...
Attema, Jl Papathanasiou, P Forsberg, Ec Xu, J Smale, St Weissman, Il
Published in
Proceedings of the National Academy of Sciences
Hematopoietic stem cells (HSC) produce all blood cell lineages by virtue of their capacity to self-renew and differentiate into progenitors with decreasing cellular potential. Recent studies suggest that epigenetic mechanisms play an important role in controlling stem cell potency and cell fate decisions. To investigate this hypothesis in HSC, we h...
Matz, C Mcdougald, D Moreno, Am Yung, Py Fitnat Yildiz Kjelleberg, S
Published in
Proceedings of the National Academy of Sciences
Persistence of the opportunistic bacterial pathogen Vibrio cholerae in aquatic environments is the principal cause for seasonal occurrence of cholera epidemics. This causality has been explained by postulating that V. cholerae forms biofilms in association with animate and inanimate surfaces. Alternatively, it has been proposed that bacterial patho...
Zhang, C Song, Y Thompson, Da Madonna, Ma Glenn Millhauser Toro, S Varga, Z Westerfield, M Gamse, J Chen, W
...
Published in
Proceedings of the National Academy of Sciences
Background adaptation is used by teleosts as one of a variety of camouflage mechanisms for avoidance of predation. Background adaptation is known to involve light sensing by the retina and subsequent regulation of melanophore dispersion or contraction in melanocytes, mediated by α-melanocyte-stimulating hormone and melanin-concentrating hormone, re...
Jiao, Jian-Wei Feldheim, David A Chen, Dong Feng
Published in
Proceedings of the National Academy of Sciences of the United States of America
In the central nervous system (CNS) of adult mammals, neurogenesis occurs in only two restricted areas, the subgranular zone (SGZ) of the hippocampus and the subventricular zone (SVZ). Isolation of multipotent progenitor cells from other CNS regions suggests that their neurogenic potential is dictated by local environmental cues. Here, we report th...
Osterfeld, Sebastian J Yu, Heng Gaster, Richard S Caramuta, Stefano Xu, Liang Han, Shu-Jen Hall, Drew A Wilson, Robert J Sun, Shouheng White, Robert L
...
Published in
Proceedings of the National Academy of Sciences of the United States of America
Magnetic nanotags (MNTs) are a promising alternative to fluorescent labels in biomolecular detection assays, because minute quantities of MNTs can be detected with inexpensive giant magnetoresistive (GMR) sensors, such as spin valve (SV) sensors. However, translating this promise into easy to use and multilplexed protein assays, which are highly so...
Jeremy Sanford Bruzik, Jp
Published in
Proceedings of the National Academy of Sciences
Ser-Arg-rich (SR) proteins play numerous roles in spliceosome assembly and the regulation of splice-site selection. Whereas considerable attention has focused on the mechanistic details of SR protein activities, little is known concerning how these splicing regulators are controlled by the cell. Here we examined the subcellular localization of prec...
