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Bidirectional radial Ca(2+) activity regulates neurogenesis and migration during early cortical column formation. PDF available through Get Fulltext Research

Rash, Brian G Ackman, James B Rakic, Pasko

Published in Science advances

Cortical columns are basic cellular and functional units of the cerebral cortex that are malformed in many brain disorders, but how they initially develop is not well understood. Using an optogenetic sensor in the mouse embryonic forebrain, we demonstrate that Ca(2+) fluxes propagate bidirectionally within the elongated fibers of radial glial cells...

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