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Common Polymorphisms in the Solute Carrier SLC30A10 are Associated With Blood Manganese and Neurological Function.

Wahlberg, Karin Kippler, Maria Alhamdow, Ayman Rahman, Syed Moshfiqur Smith, Donald R Vahter, Marie Lucchini, Roberto G Broberg, Karin

Published in Toxicological sciences : an official journal of the Society of Toxicology

Manganese (Mn) is an essential nutrient in humans, but excessive exposure to Mn may cause neurotoxicity. Despite homeostatic regulation, Mn concentrations in blood vary considerably among individuals. We evaluated if common single-nucleotide polymorphisms (SNPs) in SLC30A10, which likely encodes an Mn transporter, influence blood Mn concentrations ...

Ceruloplasmin alters the tissue disposition and neurotoxicity of manganese, but not its loading onto transferrin.

Jursa, Thomas Smith, Donald R

Published in Toxicological sciences : an official journal of the Society of Toxicology

Manganese (Mn) is a redox-active element, and whereas its uptake, disposition, and toxicity in mammals may depend in part on its oxidation state, the proteins affecting manganese oxidation state and speciation in vivo are not well known. Studies have suggested that the oxidase protein ceruloplasmin (Cp) mediates iron and manganese oxidation and loa...

Oral methylphenidate alleviates the fine motor dysfunction caused by chronic postnatal manganese exposure in adult rats....

Beaudin, Stéphane A Strupp, Barbara J Lasley, Stephen M Fornal, Casimir A Mandal, Shyamali Smith, Donald R

Published in Toxicological sciences : an official journal of the Society of Toxicology

Developmental manganese (Mn) exposure is associated with motor dysfunction in children and animal models, but little is known about the underlying neurochemical mechanisms or the potential for amelioration by pharmacotherapy. We investigated whether methylphenidate (MPH) alleviates fine motor dysfunction due to chronic postnatal Mn exposure, and wh...

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