Wahlberg, Karin Kippler, Maria Alhamdow, Ayman Rahman, Syed Moshfiqur Smith, Donald R Vahter, Marie Lucchini, Roberto G Broberg, Karin
Published in
Toxicological sciences : an official journal of the Society of Toxicology
Manganese (Mn) is an essential nutrient in humans, but excessive exposure to Mn may cause neurotoxicity. Despite homeostatic regulation, Mn concentrations in blood vary considerably among individuals. We evaluated if common single-nucleotide polymorphisms (SNPs) in SLC30A10, which likely encodes an Mn transporter, influence blood Mn concentrations ...
Jursa, Thomas Smith, Donald R
Published in
Toxicological sciences : an official journal of the Society of Toxicology
Manganese (Mn) is a redox-active element, and whereas its uptake, disposition, and toxicity in mammals may depend in part on its oxidation state, the proteins affecting manganese oxidation state and speciation in vivo are not well known. Studies have suggested that the oxidase protein ceruloplasmin (Cp) mediates iron and manganese oxidation and loa...
Beaudin, Stéphane A Strupp, Barbara J Lasley, Stephen M Fornal, Casimir A Mandal, Shyamali Smith, Donald R
Published in
Toxicological sciences : an official journal of the Society of Toxicology
Developmental manganese (Mn) exposure is associated with motor dysfunction in children and animal models, but little is known about the underlying neurochemical mechanisms or the potential for amelioration by pharmacotherapy. We investigated whether methylphenidate (MPH) alleviates fine motor dysfunction due to chronic postnatal Mn exposure, and wh...
