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Interaction of the New Monofunctional Anticancer Agent Phenanthriplatin With Transporters for Organic Cations PDF available through Get Fulltext Research

Hucke, Anna Park, Ga Young Bauer, Oliver B. Beyer, Georg Köppen, Christina Zeeh, Dorothea Wehe, Christoph A. Sperling, Michael Schröter, Rita Kantauskaitè, Marta ...

Published in Frontiers in Chemistry

Cancer treatment with platinum compounds is an important achievement of modern chemotherapy. However, despite the beneficial effects, the clinical impact of these agents is hampered by the development of drug resistance as well as dose-limiting side effects. The efficacy but also side effects of platinum complexes can be mediated by uptake through ...

The actual and potential costs of meningitis surveillance in the African meningitis belt: Results from Chad and Niger.

Irurzun-Lopez, Maite Erondu, Ngozi A Djibo, Ali Griffiths, Ulla Stuart, James M Fernandez, Katya Ronveaux, Olivier Le Gargasson, Jean-Bernard Gessner, Bradford D Colombini, Anaïs ...

Published in Vaccine

The introduction of serogroup A meningococcal conjugate vaccine in the African meningitis belt required strengthened surveillance to assess long-term vaccine impact. The costs of implementing this strengthening had not been assessed. The ingredients approach was used to retrospectively determine bacterial meningitis surveillance costs in Chad and N...

Response thresholds for epidemic meningitis in sub-Saharan Africa following the introduction of MenAfriVac®.

Trotter, Caroline L Cibrelus, Laurence Fernandez, Katya Lingani, Clément Ronveaux, Olivier Stuart, James M

Published in Vaccine

Since 2010, countries in the African meningitis belt have been introducing a new serogroup A meningococcal conjugate vaccine (MenAfriVac(®)) through mass campaigns. With the subsequent decline in meningitis due to Neisseria meningitidis serogroup A (NmA) and relative increase in meningitis due to other serogroups, mainly N. meningitidis serogroup W...

Vaccine-induced antibodies to the native, oligomeric envelope glycoproteins of primary HIV-1 isolates.

Lee, Sa Orque, R Escarpe, Pa Peterson, Ml Good, Jw Zaharias, Em Phil Berman Sheppard, Hw Shibata, R

Published in Vaccine

A simple and sensitive method for measuring antibodies to primary human immunodeficiency virus type 1 (HIV-1) isolates has been developed. The flow cytometric immuno-fluorescence assay detects antibodies that bind to the native, oligomeric form of the envelope glycoprotein (gp120) expressed on the surface of PM-1 cells infected with primary isolate...

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